Applications:

Chemotherapy-Induced Nausea/Vomiting (CINV): Prevents acute/delayed nausea from highly emetogenic chemo (e.g., cisplatin).
Moderately Emetogenic Chemo: Used with dexamethasone + 5-HT3 blockers (e.g., ondansetron).
Postoperative Nausea/Vomiting (PONV): Alternative for high-risk surgeries (less common).

Side Effects:

Common: Fatigue, hiccups, constipation, headache, loss of appetite.
Serious (Rare):

• Liver toxicity (elevated LFTs).

• Hypersensitivity (rash, anaphylaxis).

• Drug interactions (CYP3A4 inhibitor—affects warfarin, birth control, some chemo drugs).

Note: Avoid with pimozide (QT prolongation risk). IV form (fosaprepitant) available.

Dimenhydrinate is an antihistamine primarily used to prevent and treat motion sickness and nausea.

Applications:

• Prevents and relieves nausea, vomiting, and dizziness from motion sickness.

• Used for vertigo and inner ear disturbances like Ménière’s disease.

Side Effects:

• Common: drowsiness, dry mouth, dizziness, and blurred vision.

• Serious (rare): confusion (especially in elderly), fast heartbeat, and urinary retention.

Doxylamine Succinate + Pyridoxine Hydrochloride is a combination used to treat nausea and vomiting during pregnancy (morning sickness).

Applications:

• First-line treatment for morning sickness in pregnant women.

• Helps reduce nausea and vomiting without harming the fetus.

Side Effects:

• Common: drowsiness, dry mouth, dizziness, and headache.

• Serious (rare): allergic reactions, confusion, and difficulty urinating.