Applications:

• Bloating & Gas Relief:

  • Simethicone: Breaks down gas bubbles in the gut (anti-foaming agent).

  • Alverine Citrate: Relieves intestinal spasms (smooth muscle relaxant).

• Irritable Bowel Syndrome (IBS): Reduces cramping, distension, and discomfort.

• Functional GI Disorders: Eases symptoms of dyspepsia or diverticular disease.

Side Effects:

• Simethicone: Generally side-effect-free (not absorbed systemically).

• Alverine Citrate:

  • Mild: Dizziness, nausea, headache.

  • Rare: Allergic reactions (rash, itching).

Applications:

• Peptic Ulcers: Reduces gastric acid secretion (adjunct therapy).

• Hyperhidrosis: Controls excessive sweating (off-label).

• GI Spasms: Manages irritable bowel syndrome (IBS) and diverticulitis.

• Urinary Incontinence: Treats overactive bladder (less common now).

Side Effects:

• Common: Dry mouth, blurred vision, constipation, drowsiness.

• Serious (Rare):

  • Urinary retention (risk in prostate enlargement).

  • Tachycardia (fast heart rate).

  • Glaucoma exacerbation (avoid in narrow-angle glaucoma).

Applications:

• GI Spasms: Treats irritable bowel syndrome (IBS), diverticulitis, and abdominal cramps.

• Biliary/Urinary Colic: Relieves pain from gallstones or kidney stones.

• Endoscopic Procedures: Reduces intestinal motility during colonoscopy.

• Menstrual Cramps: Eases dysmenorrhea (off-label use).

Side Effects:

• Common: Dry mouth, dizziness, blurred vision (mild anticholinergic effects).

• Serious (Rare):

  • Tachycardia (fast heart rate).

  • Urinary retention (especially in elderly men with prostate issues).

  • Allergic reactions (rash, anaphylaxis).

Applications:

• Pre-Anesthesia: Reduces saliva and respiratory secretions before surgery.

• Bradycardia: Emergency treatment for abnormally slow heart rate.

• Poison Antidote: Countacts organophosphate or nerve agent poisoning.

• Ophthalmic Use: Dilates pupils for eye exams or inflammation treatment.

• GI Disorders: Relieves spasms in irritable bowel (rarely used today).

Side Effects:

• Common: Dry mouth, blurred vision, rapid heartbeat, dizziness.

• Serious:

  • Hallucinations/confusion (high doses)

  • Urinary retention

  • Glaucoma attacks (with eye drops)

  • Dangerous tachycardia (overdose)

Note:

• IV/IM use only in emergencies (hospital/EMS).

• Reverses life-threatening cholinergic toxicity (e.g., pesticide poisoning).