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    Palonosetron Hydrochloride

    Palonosetron Hydrochloride is a long-acting 5-HT3 receptor antagonist used to prevent nausea and vomiting.

    Applications:

    • Prevents acute and delayed nausea/vomiting from moderately to highly emetogenic chemotherapy.

    • Also used for postoperative nausea and vomiting.

    Side Effects:

    • Common: headache, constipation, dizziness.

    • Serious (rare): QT prolongation, hypersensitivity reactions.

    Br120.00
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    Palonosetron Hydrochloride

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    Fosaprepitant

    Fosaprepitant is an antiemetic used to prevent nausea and vomiting caused by chemotherapy.

    Applications:

    • Prevents acute and delayed nausea/vomiting from highly emetogenic chemotherapy.

    • Often used in combination with other antiemetics (like dexamethasone and a 5-HT3 antagonist).

    Side Effects:

    • Common: fatigue, headache, hiccups, and constipation.

    • Serious (rare): infusion site reactions, allergic reactions, liver enzyme elevation.

    Brands: Emend (IV).

    Br120.00
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    Fosaprepitant

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    Domperidone

    Domperidone is a dopamine antagonist used to treat nausea, vomiting, and gastrointestinal motility disorders.

    Applications:

    • Relieves nausea and vomiting.

    • Treats gastroparesis by enhancing stomach emptying.

    • Sometimes used to increase breast milk production (off-label).

    Side Effects:

    • Common: dry mouth, abdominal cramps, and headache.

    • Serious (rare): heart rhythm disorders, especially in elderly or high doses.

    Br120.00
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    Domperidone

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    Dexamethasone

    Dexamethasone is a corticosteroid used to reduce inflammation and suppress the immune system.

    Applications:

    • Treats inflammatory conditions like arthritis, allergies, and skin diseases.

    • Used in cancer therapy and autoimmune disorders.

    • Helps manage cerebral edema and severe COVID-19 symptoms.

    Side Effects:

    • Common: insomnia, mood changes, increased appetite, and weight gain.

    • Serious (long-term use): osteoporosis, high blood sugar, increased infection risk, and adrenal suppression.

    Brands: Decadron, DexPak, Ozurdex (eye implant), Maxidex (eye drops).

    Br120.00
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    Dexamethasone

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    Aprepitant

    Applications:

    Chemotherapy-Induced Nausea/Vomiting (CINV): Prevents acute/delayed nausea from highly emetogenic chemo (e.g., cisplatin).
    Moderately Emetogenic Chemo: Used with dexamethasone + 5-HT3 blockers (e.g., ondansetron).
    Postoperative Nausea/Vomiting (PONV): Alternative for high-risk surgeries (less common).

    Side Effects:

    Common: Fatigue, hiccups, constipation, headache, loss of appetite.
    Serious (Rare):

    • Liver toxicity (elevated LFTs).

    • Hypersensitivity (rash, anaphylaxis).

    • Drug interactions (CYP3A4 inhibitor—affects warfarin, birth control, some chemo drugs).

    Note: Avoid with pimozide (QT prolongation risk). IV form (fosaprepitant) available.

    Br120.00
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    Aprepitant

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    Tolterodine

    Applications:

    • Overactive Bladder (OAB): Treats urinary frequency, urgency, and incontinence.

    • Neurogenic Detrusor Overactivity: Manages bladder spasms in neurological conditions (e.g., MS, spinal injury).

    Side Effects:

    • Common: Dry mouth (35% of users), constipation, blurred vision, headache.

    • Serious (Rare):

      • QT prolongation (caution in heart disease).

      • Angioedema (swelling of face/throat).

      • Urinary retention (risk in prostate enlargement).

    Br120.00
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    Tolterodine

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    Propranolol

    Applications:

    • Heart: Treats high BP, angina, arrhythmias, prevents heart attacks

    • Migraines: Reduces frequency

    • Anxiety: Controls physical symptoms (shaking, fast heartbeat)

    • Hyperthyroidism: Manages symptoms like rapid pulse

    • Essential tremor: Decreases shaking

    Side Effects:

    • Common: Fatigue, dizziness, cold hands/feet, sleep issues

    • Serious (rare):

      • Slow heart rate, wheezing (caution in asthma patients)

      • Worsening heart failure, depression

    Note:

    • Avoid sudden stoppage (taper gradually).

    • Brands: Inderal®, Hemangeol®, generics.

    Monitor heart rate & BP. Not for asthma/COPD patients.

    Br120.00
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    Propranolol

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    Ranitidine

    Applications:

    • Used to treat gastroesophageal reflux disease (GERD), peptic ulcers, and conditions where the stomach produces too much acid (like Zollinger-Ellison syndrome).
    • Reduces stomach acid production, helping to heal ulcers and manage heartburn or acid reflux.
    • Can be used for the prevention and treatment of ulcers and conditions like indigestion.

    Side Effects:

    • Common side effects include headache, dizziness, constipation, or diarrhea.
    • Rare but serious side effects may include liver problems, irregular heartbeats, and severe allergic reactions.
    • Long-term use can occasionally lead to vitamin B12 deficiency.

    Ranitidine is effective in controlling excess stomach acid but was withdrawn from many markets (including the U.S.) in 2020 due to concerns over a potential carcinogenic impurity. For those still using it, monitoring for side effects is important, especially if taken for prolonged periods.

    Br120.00
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    Ranitidine

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