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Fosaprepitant
Fosaprepitant is an antiemetic used to prevent nausea and vomiting caused by chemotherapy.
Applications:
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Prevents acute and delayed nausea/vomiting from highly emetogenic chemotherapy.
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Often used in combination with other antiemetics (like dexamethasone and a 5-HT3 antagonist).
Side Effects:
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Common: fatigue, headache, hiccups, and constipation.
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Serious (rare): infusion site reactions, allergic reactions, liver enzyme elevation.
Brands: Emend (IV).
Br120.00Fosaprepitant
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Domperidone
Domperidone is a dopamine antagonist used to treat nausea, vomiting, and gastrointestinal motility disorders.
Applications:
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Relieves nausea and vomiting.
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Treats gastroparesis by enhancing stomach emptying.
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Sometimes used to increase breast milk production (off-label).
Side Effects:
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Common: dry mouth, abdominal cramps, and headache.
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Serious (rare): heart rhythm disorders, especially in elderly or high doses.
Br120.00Domperidone
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Aprepitant
Applications:
Chemotherapy-Induced Nausea/Vomiting (CINV): Prevents acute/delayed nausea from highly emetogenic chemo (e.g., cisplatin).
Moderately Emetogenic Chemo: Used with dexamethasone + 5-HT3 blockers (e.g., ondansetron).
Postoperative Nausea/Vomiting (PONV): Alternative for high-risk surgeries (less common).Side Effects:
Common: Fatigue, hiccups, constipation, headache, loss of appetite.
Serious (Rare):-
Liver toxicity (elevated LFTs).
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Hypersensitivity (rash, anaphylaxis).
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Drug interactions (CYP3A4 inhibitor—affects warfarin, birth control, some chemo drugs).
Note: Avoid with pimozide (QT prolongation risk). IV form (fosaprepitant) available.
Br120.00Aprepitant
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Simethicone + Algerines citrate
Applications:
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Bloating & Gas Relief:
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Simethicone: Breaks down gas bubbles in the gut (anti-foaming agent).
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Alverine Citrate: Relieves intestinal spasms (smooth muscle relaxant).
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Irritable Bowel Syndrome (IBS): Reduces cramping, distension, and discomfort.
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Functional GI Disorders: Eases symptoms of dyspepsia or diverticular disease.
Side Effects:
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Simethicone: Generally side-effect-free (not absorbed systemically).
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Alverine Citrate:
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Mild: Dizziness, nausea, headache.
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Rare: Allergic reactions (rash, itching).
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Br120.00Simethicone + Algerines citrate
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Oxybutynin
Applications:
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Overactive Bladder (OAB): Reduces urgency, frequency, and incontinence.
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Neurogenic Bladder: Manages urinary leakage in spinal cord injury/MS.
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Pediatric Enuresis: Treats bedwetting (off-label in children ≥5 yrs).
Side Effects:
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Common: Dry mouth (70% of users), constipation, blurred vision, drowsiness.
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Serious (Rare):
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Urinary retention (risk in prostate enlargement).
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Heatstroke (reduced sweating in high temperatures).
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CNS effects (confusion in elderly).
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Br120.00Oxybutynin
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Drotaverine
Applications:
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Abdominal Pain: Relieves cramps in IBS, gastritis, or menstrual discomfort.
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Biliary Colic: Eases spasms in gallbladder/bile duct disorders.
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Urinary Tract Spasms: Treats discomfort from kidney stones or UTIs.
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Gynecological Use: Reduces labor pains (off-label) and dysmenorrhea.
Side Effects:
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Common: Dizziness, nausea, mild headache.
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Rare:
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Allergic reactions (rash, itching).
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Low blood pressure (with high doses).
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Rapid heartbeat (tachycardia).
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Br120.00Drotaverine
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