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Fosaprepitant
Fosaprepitant is an antiemetic used to prevent nausea and vomiting caused by chemotherapy.
Applications:
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Prevents acute and delayed nausea/vomiting from highly emetogenic chemotherapy.
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Often used in combination with other antiemetics (like dexamethasone and a 5-HT3 antagonist).
Side Effects:
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Common: fatigue, headache, hiccups, and constipation.
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Serious (rare): infusion site reactions, allergic reactions, liver enzyme elevation.
Brands: Emend (IV).
Br120.00Fosaprepitant
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Domperidone
Domperidone is a dopamine antagonist used to treat nausea, vomiting, and gastrointestinal motility disorders.
Applications:
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Relieves nausea and vomiting.
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Treats gastroparesis by enhancing stomach emptying.
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Sometimes used to increase breast milk production (off-label).
Side Effects:
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Common: dry mouth, abdominal cramps, and headache.
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Serious (rare): heart rhythm disorders, especially in elderly or high doses.
Br120.00Domperidone
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Dimenhydrinate
Dimenhydrinate is an antihistamine primarily used to prevent and treat motion sickness and nausea.
Applications:
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Prevents and relieves nausea, vomiting, and dizziness from motion sickness.
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Used for vertigo and inner ear disturbances like Ménière’s disease.
Side Effects:
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Common: drowsiness, dry mouth, dizziness, and blurred vision.
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Serious (rare): confusion (especially in elderly), fast heartbeat, and urinary retention.
Br120.00Dimenhydrinate
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Chlorpromazine Hydrochloride
Applications:
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Psychosis (schizophrenia, mania)
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Severe nausea/vomiting
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Intractable hiccups
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Acute agitation/sedation
Side Effects:
Common: Drowsiness, dry mouth, constipation, low BP
Serious:-
Muscle spasms (EPS), tardive dyskinesia
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Neuroleptic malignant syndrome (NMS)
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QT prolongation → heart rhythm risk
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Seizures, confusion (elderly)
Avoid in: Glaucoma, Parkinson’s, heart rhythm issues.
Br120.00Chlorpromazine Hydrochloride
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Aprepitant
Applications:
Chemotherapy-Induced Nausea/Vomiting (CINV): Prevents acute/delayed nausea from highly emetogenic chemo (e.g., cisplatin).
Moderately Emetogenic Chemo: Used with dexamethasone + 5-HT3 blockers (e.g., ondansetron).
Postoperative Nausea/Vomiting (PONV): Alternative for high-risk surgeries (less common).Side Effects:
Common: Fatigue, hiccups, constipation, headache, loss of appetite.
Serious (Rare):-
Liver toxicity (elevated LFTs).
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Hypersensitivity (rash, anaphylaxis).
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Drug interactions (CYP3A4 inhibitor—affects warfarin, birth control, some chemo drugs).
Note: Avoid with pimozide (QT prolongation risk). IV form (fosaprepitant) available.
Br120.00Aprepitant
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Pantoprazole
Applications:
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Treats GERD & erosive esophagitis
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Manages peptic ulcers (including NSAID-induced)
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Controls Zollinger-Ellison syndrome acid hypersecretion
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Prevents stress ulcers in critical care patients
Side Effects:
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Common: Headache, diarrhea, nausea, abdominal pain
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Serious (rare):
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Kidney inflammation (interstitial nephritis)
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Low magnesium (with prolonged use)
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Vitamin B12 deficiency (long-term therapy)
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Note:
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IV form is preferred for acute bleeding ulcers (80mg bolus, then infusion).
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Requires monitoring: Mg²⁺ levels if used >1 year.
Br120.00Pantoprazole
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Pantoprazole
Applications:
- Used to treat gastroesophageal reflux disease (GERD), erosive esophagitis, and peptic ulcers.
- Reduces stomach acid, promoting healing of the esophagus and ulcers.
- Used in treating Zollinger-Ellison syndrome (excessive acid production).
Side Effects:
- Headache, diarrhea, nausea, and abdominal pain.
- In rare cases, can cause low magnesium levels, bone fractures, and kidney issues with long-term use.
Pantoprazole is effective in managing acid-related gastrointestinal conditions but may cause mild side effects like headache and stomach discomfort. Serious side effects are rare but should be monitored, especially with prolonged use or in individuals with kidney concerns.
Br120.00Pantoprazole
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