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    Promethazine Hydrochloride

    Promethazine Hydrochloride is an antihistamine with antiemetic, sedative, and anticholinergic properties.

    Applications:

    • Treats nausea, vomiting, and motion sickness.

    • Used as a sedative or for allergy symptoms.

    • Sometimes used pre/post-surgery for nausea control.

    Side Effects:

    • Common: drowsiness, dry mouth, dizziness.

    • Serious (rare): respiratory depression (especially in children), severe tissue damage if injected improperly.

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    Promethazine Hydrochloride

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    Fosaprepitant

    Fosaprepitant is an antiemetic used to prevent nausea and vomiting caused by chemotherapy.

    Applications:

    • Prevents acute and delayed nausea/vomiting from highly emetogenic chemotherapy.

    • Often used in combination with other antiemetics (like dexamethasone and a 5-HT3 antagonist).

    Side Effects:

    • Common: fatigue, headache, hiccups, and constipation.

    • Serious (rare): infusion site reactions, allergic reactions, liver enzyme elevation.

    Brands: Emend (IV).

    Br120.00
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    Fosaprepitant

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    Chlorpromazine Hydrochloride

    Applications:

    • Psychosis (schizophrenia, mania)

    • Severe nausea/vomiting

    • Intractable hiccups

    • Acute agitation/sedation

    Side Effects:

    Common: Drowsiness, dry mouth, constipation, low BP
    Serious:

    • Muscle spasms (EPS), tardive dyskinesia

    • Neuroleptic malignant syndrome (NMS)

    • QT prolongation → heart rhythm risk

    • Seizures, confusion (elderly)

    Avoid in: Glaucoma, Parkinson’s, heart rhythm issues.

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    Chlorpromazine Hydrochloride

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    Aprepitant

    Applications:

    Chemotherapy-Induced Nausea/Vomiting (CINV): Prevents acute/delayed nausea from highly emetogenic chemo (e.g., cisplatin).
    Moderately Emetogenic Chemo: Used with dexamethasone + 5-HT3 blockers (e.g., ondansetron).
    Postoperative Nausea/Vomiting (PONV): Alternative for high-risk surgeries (less common).

    Side Effects:

    Common: Fatigue, hiccups, constipation, headache, loss of appetite.
    Serious (Rare):

    • Liver toxicity (elevated LFTs).

    • Hypersensitivity (rash, anaphylaxis).

    • Drug interactions (CYP3A4 inhibitor—affects warfarin, birth control, some chemo drugs).

    Note: Avoid with pimozide (QT prolongation risk). IV form (fosaprepitant) available.

    Br120.00
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    Aprepitant

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    Hyoscine/Scopolamine Butyl bromide

    Applications:

    • GI Spasms: Treats irritable bowel syndrome (IBS), diverticulitis, and abdominal cramps.

    • Biliary/Urinary Colic: Relieves pain from gallstones or kidney stones.

    • Endoscopic Procedures: Reduces intestinal motility during colonoscopy.

    • Menstrual Cramps: Eases dysmenorrhea (off-label use).

    Side Effects:

    • Common: Dry mouth, dizziness, blurred vision (mild anticholinergic effects).

    • Serious (Rare):

      • Tachycardia (fast heart rate).

      • Urinary retention (especially in elderly men with prostate issues).

      • Allergic reactions (rash, anaphylaxis).

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    Hyoscine/Scopolamine Butyl bromide

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    Ranitidine

    Applications:

    • Used to treat gastroesophageal reflux disease (GERD), peptic ulcers, and conditions where the stomach produces too much acid (like Zollinger-Ellison syndrome).
    • Reduces stomach acid production, helping to heal ulcers and manage heartburn or acid reflux.
    • Can be used for the prevention and treatment of ulcers and conditions like indigestion.

    Side Effects:

    • Common side effects include headache, dizziness, constipation, or diarrhea.
    • Rare but serious side effects may include liver problems, irregular heartbeats, and severe allergic reactions.
    • Long-term use can occasionally lead to vitamin B12 deficiency.

    Ranitidine is effective in controlling excess stomach acid but was withdrawn from many markets (including the U.S.) in 2020 due to concerns over a potential carcinogenic impurity. For those still using it, monitoring for side effects is important, especially if taken for prolonged periods.

    Br120.00
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    Ranitidine

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