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    Ranitidine

    Applications:

    • Used to treat gastroesophageal reflux disease (GERD), peptic ulcers, and conditions where the stomach produces too much acid (like Zollinger-Ellison syndrome).
    • Reduces stomach acid production, helping to heal ulcers and manage heartburn or acid reflux.
    • Can be used for the prevention and treatment of ulcers and conditions like indigestion.

    Side Effects:

    • Common side effects include headache, dizziness, constipation, or diarrhea.
    • Rare but serious side effects may include liver problems, irregular heartbeats, and severe allergic reactions.
    • Long-term use can occasionally lead to vitamin B12 deficiency.

    Ranitidine is effective in controlling excess stomach acid but was withdrawn from many markets (including the U.S.) in 2020 due to concerns over a potential carcinogenic impurity. For those still using it, monitoring for side effects is important, especially if taken for prolonged periods.

    Br120.00
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    Ranitidine

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    Darifenacin

    Applications:

    • Overactive Bladder (OAB): Treats frequent urination, urgency, and incontinence.

    • Neurogenic Detrusor Overactivity: Manages bladder control issues in neurological conditions (e.g., MS, spinal cord injury).

    Side Effects:

    • Common: Dry mouth, constipation, blurred vision, dizziness.

    • Serious (Rare):

      • Severe allergic reactions (rash, swelling).

      • Worsening glaucoma (caution in patients with eye conditions).

      • Urinary retention (in men with prostate enlargement).

    Br120.00
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    Darifenacin

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    Hyoscine/Scopolamine Butyl bromide

    Applications:

    • GI Spasms: Treats irritable bowel syndrome (IBS), diverticulitis, and abdominal cramps.

    • Biliary/Urinary Colic: Relieves pain from gallstones or kidney stones.

    • Endoscopic Procedures: Reduces intestinal motility during colonoscopy.

    • Menstrual Cramps: Eases dysmenorrhea (off-label use).

    Side Effects:

    • Common: Dry mouth, dizziness, blurred vision (mild anticholinergic effects).

    • Serious (Rare):

      • Tachycardia (fast heart rate).

      • Urinary retention (especially in elderly men with prostate issues).

      • Allergic reactions (rash, anaphylaxis).

    Br120.00
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    Hyoscine/Scopolamine Butyl bromide

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    Aprepitant

    Applications:

    Chemotherapy-Induced Nausea/Vomiting (CINV): Prevents acute/delayed nausea from highly emetogenic chemo (e.g., cisplatin).
    Moderately Emetogenic Chemo: Used with dexamethasone + 5-HT3 blockers (e.g., ondansetron).
    Postoperative Nausea/Vomiting (PONV): Alternative for high-risk surgeries (less common).

    Side Effects:

    Common: Fatigue, hiccups, constipation, headache, loss of appetite.
    Serious (Rare):

    • Liver toxicity (elevated LFTs).

    • Hypersensitivity (rash, anaphylaxis).

    • Drug interactions (CYP3A4 inhibitor—affects warfarin, birth control, some chemo drugs).

    Note: Avoid with pimozide (QT prolongation risk). IV form (fosaprepitant) available.

    Br120.00
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    Aprepitant

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    Fosaprepitant

    Fosaprepitant is an antiemetic used to prevent nausea and vomiting caused by chemotherapy.

    Applications:

    • Prevents acute and delayed nausea/vomiting from highly emetogenic chemotherapy.

    • Often used in combination with other antiemetics (like dexamethasone and a 5-HT3 antagonist).

    Side Effects:

    • Common: fatigue, headache, hiccups, and constipation.

    • Serious (rare): infusion site reactions, allergic reactions, liver enzyme elevation.

    Brands: Emend (IV).

    Br120.00
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    Fosaprepitant

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    Ondansetron

    Ondansetron is a 5-HT3 receptor antagonist used to prevent and treat nausea and vomiting.

    Applications:

    • Prevents nausea and vomiting from chemotherapy, radiation, and surgery.

    • Sometimes used for severe morning sickness in pregnancy.

    Side Effects:

    • Common: headache, constipation, dizziness.

    • Serious (rare): QT prolongation, allergic reactions, serotonin syndrome (when combined with other serotonergic drugs).

    Br120.00
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    Ondansetron

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