Applications:

• Overactive Bladder (OAB): Treats urinary frequency, urgency, and incontinence.

• Neurogenic Detrusor Overactivity: Manages bladder spasms in neurological conditions (e.g., MS, spinal injury).

Side Effects:

• Common: Dry mouth (35% of users), constipation, blurred vision, headache.

• Serious (Rare):

  • QT prolongation (caution in heart disease).

  • Angioedema (swelling of face/throat).

  • Urinary retention (risk in prostate enlargement).

Applications:

• Bloating & Gas Relief:

  • Simethicone: Breaks down gas bubbles in the gut (anti-foaming agent).

  • Alverine Citrate: Relieves intestinal spasms (smooth muscle relaxant).

• Irritable Bowel Syndrome (IBS): Reduces cramping, distension, and discomfort.

• Functional GI Disorders: Eases symptoms of dyspepsia or diverticular disease.

Side Effects:

• Simethicone: Generally side-effect-free (not absorbed systemically).

• Alverine Citrate:

  • Mild: Dizziness, nausea, headache.

  • Rare: Allergic reactions (rash, itching).

Applications:

• Peptic Ulcers: Reduces gastric acid secretion (adjunct therapy).

• Hyperhidrosis: Controls excessive sweating (off-label).

• GI Spasms: Manages irritable bowel syndrome (IBS) and diverticulitis.

• Urinary Incontinence: Treats overactive bladder (less common now).

Side Effects:

• Common: Dry mouth, blurred vision, constipation, drowsiness.

• Serious (Rare):

  • Urinary retention (risk in prostate enlargement).

  • Tachycardia (fast heart rate).

  • Glaucoma exacerbation (avoid in narrow-angle glaucoma).