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    Fosaprepitant

    Fosaprepitant is an antiemetic used to prevent nausea and vomiting caused by chemotherapy.

    Applications:

    • Prevents acute and delayed nausea/vomiting from highly emetogenic chemotherapy.

    • Often used in combination with other antiemetics (like dexamethasone and a 5-HT3 antagonist).

    Side Effects:

    • Common: fatigue, headache, hiccups, and constipation.

    • Serious (rare): infusion site reactions, allergic reactions, liver enzyme elevation.

    Brands: Emend (IV).

    Br120.00
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    Fosaprepitant

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    Aprepitant

    Applications:

    Chemotherapy-Induced Nausea/Vomiting (CINV): Prevents acute/delayed nausea from highly emetogenic chemo (e.g., cisplatin).
    Moderately Emetogenic Chemo: Used with dexamethasone + 5-HT3 blockers (e.g., ondansetron).
    Postoperative Nausea/Vomiting (PONV): Alternative for high-risk surgeries (less common).

    Side Effects:

    Common: Fatigue, hiccups, constipation, headache, loss of appetite.
    Serious (Rare):

    • Liver toxicity (elevated LFTs).

    • Hypersensitivity (rash, anaphylaxis).

    • Drug interactions (CYP3A4 inhibitor—affects warfarin, birth control, some chemo drugs).

    Note: Avoid with pimozide (QT prolongation risk). IV form (fosaprepitant) available.

    Br120.00
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    Aprepitant

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    Oxybutynin

    Applications:

    • Overactive Bladder (OAB): Reduces urgency, frequency, and incontinence.

    • Neurogenic Bladder: Manages urinary leakage in spinal cord injury/MS.

    • Pediatric Enuresis: Treats bedwetting (off-label in children ≥5 yrs).

    Side Effects:

    • Common: Dry mouth (70% of users), constipation, blurred vision, drowsiness.

    • Serious (Rare):

      • Urinary retention (risk in prostate enlargement).

      • Heatstroke (reduced sweating in high temperatures).

      • CNS effects (confusion in elderly).

    Br120.00
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    Oxybutynin

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    Atropine Sulphate

    Applications:

    • Pre-Anesthesia: Reduces saliva and respiratory secretions before surgery.

    • Bradycardia: Emergency treatment for abnormally slow heart rate.

    • Poison Antidote: Countacts organophosphate or nerve agent poisoning.

    • Ophthalmic Use: Dilates pupils for eye exams or inflammation treatment.

    • GI Disorders: Relieves spasms in irritable bowel (rarely used today).

    Side Effects:

    • Common: Dry mouth, blurred vision, rapid heartbeat, dizziness.

    • Serious:

      • Hallucinations/confusion (high doses)

      • Urinary retention

      • Glaucoma attacks (with eye drops)

      • Dangerous tachycardia (overdose)

    Note:

    • IV/IM use only in emergencies (hospital/EMS).

    • Reverses life-threatening cholinergic toxicity (e.g., pesticide poisoning).

    Br120.00
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    Atropine Sulphate

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    Octreotide

    Applications:

    • Treats acromegaly (reduces growth hormone)

    • Manages neuroendocrine tumors (controls carcinoid/VIPoma symptoms)

    • Stops severe GI bleeding (esophageal varices, ulcers)

    • Closes pancreatic/intestinal fistulas

    Side Effects:

    • Common: Nausea, diarrhea, gallstones, blood sugar changes

    • Serious (rare): Heart rhythm issues, thyroid dysfunction

    Note: Requires monitoring for gallbladder and metabolic effects. Available in short-acting (daily) and long-acting (monthly) forms.

    Br120.00
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    Octreotide

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    Ranitidine

    Applications:

    • Used to treat gastroesophageal reflux disease (GERD), peptic ulcers, and conditions where the stomach produces too much acid (like Zollinger-Ellison syndrome).
    • Reduces stomach acid production, helping to heal ulcers and manage heartburn or acid reflux.
    • Can be used for the prevention and treatment of ulcers and conditions like indigestion.

    Side Effects:

    • Common side effects include headache, dizziness, constipation, or diarrhea.
    • Rare but serious side effects may include liver problems, irregular heartbeats, and severe allergic reactions.
    • Long-term use can occasionally lead to vitamin B12 deficiency.

    Ranitidine is effective in controlling excess stomach acid but was withdrawn from many markets (including the U.S.) in 2020 due to concerns over a potential carcinogenic impurity. For those still using it, monitoring for side effects is important, especially if taken for prolonged periods.

    Br120.00
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    Ranitidine

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