Metoclopramide Hydrochloride is a dopamine antagonist used to treat nausea, vomiting, and delayed gastric emptying.

Applications:

• Treats nausea and vomiting from various causes, including chemotherapy and migraines.

• Manages gastroparesis by enhancing stomach motility.

• Used for GERD when other treatments fail.

Side Effects:

• Common: drowsiness, fatigue, restlessness.

• Serious (rare): tardive dyskinesia (involuntary movements), Parkinson-like symptoms, depression.

Meclizine Hydrochloride is an antihistamine used to treat motion sickness and vertigo.

Applications:

• Prevents and treats nausea, vomiting, and dizziness from motion sickness.

• Manages vertigo from inner ear disorders like Ménière’s disease.

Side Effects:

• Common: drowsiness, dry mouth, and blurred vision.

• Serious (rare): confusion, especially in older adults.

Applications:

• Psychosis (schizophrenia, mania)

• Severe nausea/vomiting

• Intractable hiccups

• Acute agitation/sedation

Side Effects:

Common: Drowsiness, dry mouth, constipation, low BP
Serious:

• Muscle spasms (EPS), tardive dyskinesia

• Neuroleptic malignant syndrome (NMS)

• QT prolongation → heart rhythm risk

• Seizures, confusion (elderly)

Avoid in: Glaucoma, Parkinson’s, heart rhythm issues.