Applications:

• Treats severe GERD/ulcers (when oral therapy fails)

• Manages Zollinger-Ellison syndrome (acid hypersecretion)

• Prevents acid aspiration during surgery

• Reduces rebleeding risk after endoscopic treatment

Side Effects:

• Common: Headache, nausea, injection-site pain

• Serious (rare): Kidney injury, low magnesium, bone fractures (long-term use)

Note: Requires kidney/magnesium monitoring with prolonged IV use. Administered once daily (40mg). Brands include Losec® IV and generics.